![]() However, human laboratory and clinical research on psychedelics largely came to a halt in the early 1970s. ![]() At the same time, clinical applications were evaluated to include the treatment of addictive behaviors by psychedelics ( Johnson & Griffiths, 2017). The basic science of psychedelics drugs, including the remarkable potency of lysergic acid diethylamide (LSD), added to the emerging biobehavioral model of brain function supplanting the existing dominance of psychodynamic models. Interest in psychedelics has grown in recent years given their marked potential as clinical therapeutics, a utility that was first speculated during the 1950s and 1960s and was freshly renewed in focus over the past decade following a period of relative research dormancy.ĭuring mid-20th century, the scientific evaluation of psychedelics and the treatment of tens of thousands of patients with psychedelics was described in some of the leading medical and scientific journals. ![]() ![]() ![]() Psychedelics (sometimes referred to as hallucinogens see Section 2 for a history of naming conventions) are a collection of psychoactive compounds that act as agonists or partial agonists at the serotonin 2A receptor (5-HT2AR). Johnson, in Advances in Pharmacology, 2022 1 Introduction ![]()
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